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However, their therapeutic index is often narrowas exemplified by deferoxamine, which, despite being well-studied, is currently limited to treating acute iron poisoning and conditions involving chronic blood transfusions (e.g., thalassemia)

10.1007/s12035-025-05538-5 Mol Neurobiol

For example, in a randomized, double-blind, placebo-controlled trial in 60 participants diagnosed with an acute MI, neither mortality nor echocardiographic measures of cardiac function differed between patients treated with intravenous L-carnitine (6 g/day) for seven days followed by oral L-carnitine (3 g/day) for three months and those given a placebo (49)

Because of the slow onset of action of DMARDs, corticosteroids & NSAIDs are often more heavily used as adjunct drugs during the early phase of RA treatment before the full effect of a DMARD is achieved

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