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These are deemed essential fatty acids because they must be acquired through the diet, as the human body cannot synthesize them independently

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Patients should disclose a history of pancreatitis, gallbladder disease, severe gastrointestinal disease, kidney disease or dehydration risk, use of diabetes medications such as insulin or sulfonylureas, pregnancy or plans for pregnancy, any personal or family history of medullary thyroid carcinoma or MEN2, and a history of diabetic retinopathy

The addition of the palmitoyl chain significantly improves the cutaneous penetration of both peptides

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Hydroxocobalamin is considered safe for use during pregnancy and breastfeeding when clinically indicated