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The occurrence of a primary injury is often followed by a series of secondary injuries, including disruption of the bloodspinal cord barrier, neuroinflammation, and oxidative stress (OS)-induced damage, among others, and this phase may last for extended periods [1, 2]

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Activated fibroblasts may either differentiate into myofibroblasts or adipocytes, or they may secrete hyaluronic acid and prostaglandin E2 (Figure 4)