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Alpha Yohimbine (Rauwolscine) at 1.5mg is the most potent per-milligram compound in the formula. Rauwolscine has approximately 4-8x the binding affinity for alpha-2 adrenergic receptors versus standard Yohimbine at 1.5mg it produces meaningful alpha-2 receptor blockade, removing the inhibition on fat cell lipolysis and amplifying the adrenergic stimulant experience through receptor occupancy that caffeine and PEA compounds cannot achieve through their own mechanisms. Users sensitive to Alpha Yohimbine experience anxiety, elevated heart rate, and sweating which is why starting at half scoop (0.75mg Alpha Yohimbine) before advancing to the full dose is particularly important for this specific ingredient. Alpha Yohimbine is prohibited by WADA.

177 The RHOA-mediated increase in bloodbrain barrier permeability has been attributed to increased phosphorylation of the myosin light chain and contraction of actomyosin, pulling intercellular adhesions apart

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