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Energy output may go up for a short time and then plateau, while anxiety escalates quickly, leading to a state of wired anxiety

A similar protective effect of vagotomy was also shown in Lactobacillus and IL-6-induced mouse depression models, suggesting that the vagus nerve plays a crucial role in gut-immune-brain crosstalk [265]

Danelsdttir HB, Aspelund T, Shen Q, Halldorsdottir T, Jakobsdttir J, Song H, et al

Cigarette smoke extract-induced oxidative stress and fibrosis-related genes expression in orbital fibroblasts from patients with graves' Ophthalmopathy

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