A big one is that these medications impact hormones, which "have wide-ranging effects throughout the body," Dr
They are incretin mimetics, a fancy term that means they mimic the action of a natural hormone your body produces called glucagon-like peptide-1 (GLP-1)
cancerres.aacrjournals.org, doi:10.1158/0008-5472.CAN-04-3543
Failures in the preclinical trials could possibly be attributed to improper dose extrapolation from mouse models, duration of treatments being too short, or the fact that mGluR5 inhibition is preferentially effective in a younger populationparameters that can be adjusted in future trials [134, 135]
S.ChatterjeeT
Burg D, Riepsaame J, Pont C, Mulder G, van de Water B