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In the view of the pH of the GI tract differs dramatically (pH= 1.5 in the stomach, pH= 8 in the lower small intestine and colon), this goal is not easily achieved

J Endocrinol (2012) 215(2):189206

Metformin is a traditional drug for the treatment of type 2 diabetes

Springer: Berlin, Heidelberg, 1993, pp 145188, Merrer JL, Becker JAJ, Befort K, Kieffer BL

Hoppe Seylers Z Physiol Chem 365:195212

The major enzyme superfamilies comprise cytochrome P450 monooxygenases (P450s), glutathione S-transferases (GSTs), carboxylesterases (COEs), ATP-binding cassette (ABC) transporters, and UDP-glycosyltransferases (UGTs) [5, 26, 36-39] (Figure 2)