Studies show that people who discontinue GLP-1 medications typically regain weight within several months
For procedures, surgery, or pregnancy planning, the multi-week clearance matters, which is why timing the last dose carefully (with a provider) is part of using any long-acting GLP-1 drug safely
Be prepared for flow changes during the first few months of treatment
It was suggested that this action was mediated by activation of STAT5-dependent steroidogenesis by GH and through stimulation of Leydig cell proliferation (80), although other studies in animals failed to demonstrate any androgenic effect (88, 100)
If you think you are having a medical emergency, call 911
At the same time 32% of those studied experienced adverse events, including liver dysfunction and one case of anaphylaxis (Alzahrani et al., Cureus 2025, PMID 40013212)