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This discrepancy is expected, and reported events could be because the pharmacokinetics of intravenous methylene blue are different than that of oral methylene blue

It was meant to rule out deficiency, but the result points the other direction

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Alcohol Clin Exp Res 40(12):24742481 Kaminiw K, Pajk M, Pajk R, Paprocka J (2021) Pyridoxine-dependent epilepsy and antiquitin deficiency resulting in neonatal-onset refractory seizures