individuals may find relief by reducing their intake of high-fat foods and increasing fiber-rich options, which can promote better digestion and gallbladder function
Nandi et al., 2020)
Proposed pathways include modulation of multiple neurotransmitter systems (influencing serotonin, dopamine, norepinephrine, GABA, glutamate levels), possible involvement of NMDA receptors, alpha-1 adrenergic signaling (e.g., potentiating pineal acetyltransferase activity), inhibition of somatostatin release via dopaminergic routes, reduced ACTH/cortisol for stress buffering, and stimulated growth hormone or somatoliberin secretion
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Poria cocos acidic polysaccharides (PCAP) significantly reduced the mRNA and protein expression levels of NLRP3, ASC, caspase-1, IL-1, and IL-18 in the prefrontal cortex of rats in a chronic unpredictable stress model ( Gastrodia elata polysaccharides (GEP) exhibited the ability to attenuate the relative mRNA expression of pro-inflammatory cytokines TNF- and IL-1 in hippocampal tissues of depressed mice, thereby exerting a neuroprotective effect and ameliorating LPS-induced depressive-like behaviors in mice ( Momordica charantia polysaccharides (MCP, 200 and 400 mg/kg) also decreased hippocampal levels of IL-1, IL-6, and TNF-, alleviating depressive behaviors in mice subjected to chronic social frustration stress ( The intervention of Astragalus polysaccharide (APS) significantly reduced the levels of hippocampal TNF-, IL-1, and IL-6 in rats with CUS-induced depression (Wang et al., 2018
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