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Nurk E, Tell GS, Vollset SE, Nygard O, Refsum H, Ueland PM

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NAD + can inhibit the release of presynaptic glutamate, reduce the induced excitatory postsynaptic current, and weaken excitatory neurotransmission, thereby inhibiting bilirubin-induced hyperexcitability of ventral cochlear nucleus neurons [124]

mGlu5, metabotropic glutamate type 5

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After verifying oxidizing influences on Mia40 in vivo , we next wanted to test which reducing pathways act on Mia40 or more specifically whether the redox state of Mia40 is susceptible to changes in E GSH (Figure 8A)