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Introducing retatrutide Retatrutide, also known as LY3437943, is a novel triple-hormone receptor agonist that targets the glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1), and glucagon (GCG) receptors

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When researchers tested exendin-4 in laboratory and animal studies, they confirmed it triggered the same appetite and blood sugar pathways as human GLP-1

Real-world dosing requires flexibility, and the compounded format from Empower supports that flexibility far better than fixed-dose pens

However, many users find that injection day brings increased nausea and reduced appetite, which makes it harder to take supplements with food

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