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Sepsis and cerebral dysfunction: BBB damage, neuroinflammation, oxidative stress, apoptosis and autophagy as key mediators and the potential therapeutic approaches

Although challenges such as limited bioavailability and safety concerns continue to impede clinical translation, these limitations may be addressed through the optimization of delivery strategies, rigorous pharmacokinetic and toxicological assessments, mechanism-driven in vitro , in vivo , ex vivo studies, and well-designed clinical trials

[DOI] [PubMed] [Google Scholar] 213.Guo S.-S., Gao X.-F., Gu Y.-R., Wan Z.-X., Lu A.M., Qin Z.-H., Luo L

The role of Fbx2 after SCI has not been examined, but abolishing -secretase reduces neuronal recovery after SCI, associated with reduced myelination

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