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The receptors adapt

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STS protects against cerebral injury, promotes angiogenesis and neural regeneration, inhibits neuronal apoptosis, and improves ischemia-induced BBB damage (Morton et al., 2015)

Another reason is tolerability

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Among animal species, ICR mice demonstrated the largest effect size, accompanied by a concomitant reduction in heterogeneity [SMD = 3.27, 95% CI (2.75,3.80), p = 0.008, I 2 = 65.5%]