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This reaction simultaneously depletes two critically important metabolic cofactors: SAM (the universal methyl donor for hundreds of epigenetic and biosynthetic reactions) and nicotinamide (the precursor for NAD+ biosynthesis via the salvage pathway)

To further determine whether EV-induced migration is endocytosis-dependent, cells were pretreated with the dynamin inhibitor dynasore

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Therefore, further clinical data are needed to validate this observation

MessaoudiMLalondeRViolleNJavelotHDesorDNejdiAet al

Accepted 2021-4-28