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Pro-inflammatory cytokines such as TNF- , IL-1, and IL-6 can enhance BBB permeability by altering tight junction proteins, resulting to a loss of barrier integrity

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This is encouraging but limited - animal results do not always carry over to humans, and this is one study, not a body of evidence

Changes to Medicare and Medicaid linked to the TrumpRx initiative are structured as phased implementations that expand coverage and negotiate co-pay structures, with significant milestones anticipated through 20252026

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