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This project will help us reduce these risks by determining the genes that affect the production of cardiac glycosides and their biosynthetic pathways

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Mass spectrometry data acquisition Samples were analysed using the EASY-nLCTM 1000 system coupled to an Orbitrap FusionTM TribridTM Mass Spectrometer (both Thermo Scientific) applying a semi-targeted data-dependent acquisition method with an inclusion list for the peptide targets of interest

The collected images were automatically processed with KAMO 28 , and XDS 29 was used for integrating and scaling data from the 21 best-diffracting crystals for GLP-1RPF-06372222Fab7F38

These manufacturing challenges contribute to FOXO4-DRI's high price relative to smaller research peptides