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In streptozotocin-induced diabetic mice, metformin has been shown to significantly improve sperm count, testicular proliferation, and testosterone levels, which may depend on elevated leptin levels and the expression of its receptor Ob-R in the testis of mice after administration of metformin (Annie et al
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4 Challenges and future directions 4.1 Safety considerations The safety profile of dual or triple receptor agonists targeting GLP-1, GIP, and GCG receptors in the treatment of MASLD and related metabolic disorders warrants careful evaluation
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The MOVE
