As we have discussed before, hyperpigmentation is caused due to overproduction of melanin in the skin
The preclinical studies do provide consistent evidence for certain effects
Phosphorylated CREB translocates to the nucleus where it binds to cAMP response elements (CREs) in DNA, upregulating transcription of the growth hormone gene and other genes involved in GH synthesis and secretion
Simultaneously, even well-stored peptides undergo gradual hydrolysis, a chemical reaction with water that cleaves peptide bonds and creates inactive fragments
This neurotoxic environment is believed to be a primary driver of the debilitating cognitive dysfunction, or 'brain fog,' that patients experience daily
An empty stomach allows the peptide to pass through the digestive system with less interference, maximizing its availability to the bodys tissues