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"If you have any symptoms of a blocked stone or infection, see your doctor or go to an emergency department as quickly as possible for assessment and treatment," says Dr

Mattei AE, Gutierrez AH, Martin WD, Terry FE, Roberts BJ, Rosenberg AS, De Groot AS

These symptoms may indicate a serious reaction

Bioinformatics 36 (21), 51595168 (2021)

In all, persistent tissue injury provokes chronic inflammation and an increase of pro-fibrotic factors, such as TGF-1, ROS, PAI-1, ROCK, TNF, and TIMPs, which induce the phenotype transformation of precursor cells to myofibroblasts