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Glutathione functions through redox cycling between its reduced (GSH) and oxidized (GSSG) forms, maintaining cellular redox balance and protecting biomolecules from oxidative modification

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Sun et al., 2021)

Additional biomarkers such as homocysteine and methylmalonic acid (MMA) were also considered to evaluate functional deficiency

This variability complicates efforts to standardize treatment and calls for a more personalized approach rather than blanket recommendations [48, 49]

These findings offer valuable insights into the diverse ways in which metformin can modulate oxidative stress in different cellular contexts (Ouslimani et al., 2005)