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After 1:1 propensity score matching, there were 3,048 patients in each cohort
1 shows Remethylation of Methionine and Transulferation Pathways
Accordingly, pharmacological inhibition of SLC7A11 or cysteine deprivation blocks GSH synthesis, leads to GSH depletion, and induces ferroptosis by disabling the antioxidant defense system 85,137
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The binding affinity is so strong that the copper remains complexed with the peptide during transport and only releases at the appropriate enzymatic sites