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(2022) 69(6):e29564

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When levels are low, cells are left more vulnerable to oxidative damage accelerating the aging process and increasing the risk of various chronic diseases

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Studies have demonstrated that ethosomal gels had higher transdermal flow and skin deposition than normal gels, proving their usefulness in delivering medicinal medications such as Spironolactone for acne treatment [130]

To verify this hypothesis, it is required to exclude macrophage polarization or epithelial-mesenchymal transformation (EMT) process because both processes might occur during the disease progression