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Its exact mechanism of action remains partially elucidated, but evidence suggests it interacts with GABAergic, serotonergic, and hypothalamic pathways to influence central nervous system activity

Detection of nitrotyrosine in aging and osteoarthritic cartilage: Correlation of oxidative damage with the presence of interleukin-1beta and with chondrocyte resistance to insulin-like growth factor 1

The first step to breaking this vicious cycle is identifying and eliminating the triggers that perpetuate this cycle, using a Root Cause approach

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doi:10.1007/s40279-016-0669-8 Kloss JD, Perlis ML, Zamzow JA, Culnan EJ, Gracia CR

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