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Splenomegaly: abnormally large spleen

The needle should be inserted at a 90-degree angle for most patients, though very thin individuals may need to use a 45-degree angle or pinch the skin to ensure subcutaneous rather than intramuscular injection

Avoid repeated freezing and thawing , as this may lead to degradation and reduced peptide activity

Adverse Effect Profile and Safety The most common adverse effects include gastrointestinal intolerance (nausea, vomiting, diarrhea), transient fatigue, and early satiety

Quality VerificationConfirmed by RP-HPLC analysis

Many patients taking GLP-1 medications like semaglutide ask whether adding B12 supplementation is necessary or safe