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Unlike peptide, the binding of compound 2 and other small molecule modulators require a complementary conformation of the ECD for ligand recognition, such that the N-terminal -helix of the compound 2GLP-1RG s deeply inserted to the orthosteric binding pocket as opposed to other GLP-1R structures (Fig

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Koh AS, Pan A, Wang R, Odegaard AO, Pereira MA, Yuan JM, Koh WP

SCF/ -TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner