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We accept that some people need more help, that difficult decisions have to be taken and that when we waste resources we waste opportunities for others

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The study follows a cautious, stepwise dose-escalation approach: starting from the maximum recommended starting dose and moving upward only after a thorough safety review at each level

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For instance, doxorubicin does not elicit significant effects on oxygen levels and fails to ameliorate IFP in breast cancer patients [46]