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They are now commonly used when: Metformin alone is no longer enough Weight gain is contributing to worsening glucose control There is a need to minimise hypoglycaemia risk Someone has existing cardiovascular disease or multiple risk factors For many people, GLP-1 therapy can delay or reduce the need for insulin, or allow insulin doses to be kept lower and safer

Das bedeutet jedoch nicht, dass die Substanzen frei von Risiken wren

Ohnuma, K., Dang, N

Disrupted BDNF synthesis reduces synaptic plasticity (46), as well as glutamate and other excitatory neuron responses, which may contribute to the pathogenesis of depression (94)

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