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The urine ACR was significantly associated with higher mortality at an ACR of 1.13 mg/mmol to 3.28 mg/mmol compared with 2.2 mg/mmol is 11-fold higher vs those with an ACR 1.6 mg/mmol vs those with an ACR of 2.0 mg/mmol [34]

Previously, nicotinamide mononucleotide (NMN) treatment has been associated with its ability to activate the Nrf2/keap1/NQO1 pathway, inhibiting A-induced oxidative damage in AD mice [56]

The relatively small numbers (n = 1989) and the short duration of the study require caution, but the results appear highly promising while awaiting the results of ongoing studies (SURPASS-CVOT) [66]

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doi: 10.2337/dc10-1333 12