doi: 10.1155/2015/756120 63 ErcalN.Gurer-OrhanH.Aykin-BurnsN
Proinflammatory cytokines, such as tumor necrosis factor-alpha (TNF-), interleukin-1 beta, and interferon-gamma (IFN-), promote ROS production, while ROS scavengers such as pyrrolidine dithiocarbamate and N-acetyl-cysteine (NAC) can reduce the ROS levels induced by these cytokines 14
Several signaling pathways are involved in cell anti-proliferation and apoptosis in human cells, as shown in Figure 3
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Although there is some evidence for PP production within the CNS, circulating PP can enter the brain, so clearly there is a requirement for the opposing actions of peripherally and centrally administered exogenous PP to be further examined
The following figure shows that inflammation caused by hitting your thumb with a hammer, exposure to UV light, radiation, smoking, and air pollution are all sources of free radicals