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The first attempts to measure intestinal permeability in IBD were performed in the late seventies by rectal instillation of radioiodine-labeled albumin and by measuring later the radioactivity in the plasma in healthy subjects and patients with UC (101)

administered BPC 157 (10mcg/kg or 10 ng/kg) orally, in drinking water (12 ml/rat/day) or intraperitoneally (once daily, first application 30 min following surgery to test its effects on short bowel syndrome in rats, observing the effectiveness of both forms of administration [24]

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