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Improved GH pulsatility is metabolically flexible and could potentially restore normal cycles in women with previous metabolic abnormalities

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2009 Feb;181(2):741-51. PMID: 19091331

In particular, the inhibition of CRHR2 in pancreatic SST-secreting cells by Ast2B promoted insulin release from neonatal islets in the resting state, and Ast2B administration caused an increase in the blood insulin level (Figs