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(4) Intracellular TAAR1 activation: Elevated cytoplasmic tyramine activates trace amine-associated receptor 1 (TAAR1), promoting signaling pathways that result in phosphorylation of the NET transporter, modify transporter function to cause it to switch to reverse transport mode (rNET)

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It helps to actively inhibit goblet cell hyperplasiathe pathological overproliferation of mucus-producing cells in the airway liningand reduces the overall hypersecretion of mucus that is constantly triggered by chronic pulmonary inflammation

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