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Compounded tirzepatide usage has been associated with the potential development of thyroid tumors, including thyroid cancer

de Mello AH, Costa AB, Engel JDG, Rezin GT (2018) Mitochondrial dysfunction in obesity

By reassessing these systems through the lens of modern peptide pharmacology and systems biology, this review seeks to distinguish between failed biology and failed pharmacology, identify the classes of peptides most amenable to renewed development, and articulate principles that can guide future discovery efforts

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Combination therapy has shown somewhat higher rates of GI events compared to either monotherapy, and slow, gradual dose titration significantly improves tolerability