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These mutations alter the activity of the encoded enzymes such that instead of converting isocitrate to 2-oxoglutarate (-ketoglutarate), while also generating NADPH, the mutant IDH enzymes reduce 2-oxoglutarate (-ketoglutarate) to 2-hydroxyglutarate (2-HG) while simultaneously oxidizing NADPH to NAPD +

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Adverse effects reported for glp1 agonism While GLP-1 receptor agonists have become extremely popular over recent years, especially in the treatment and management of type 2 diabetes and obesity, we would be remiss not to discuss the adverse side effects of these medications

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