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Thymosin beta-4 activates integrin-linked kinase in endothelial cells and promotes angiogenesis

Due to the potential of GLP-1R antagonists to modulate T-cell regulation and the evidence that enhancing T-cell infiltration can effectively transform cold tumors into hot tumors (2729), it is plausible that combining GLP-1R antagonists with ICIs may synergistically modulate T-cell-mediated immune sensitivity to improve tumor treatment outcomes

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Previous studies have linked p53 to apoptosis in VSMCs (77,78), although these investigations have been largely confined to the process of atherosclerotic plaque formation

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