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In this study, preproinsulin-specific CTLs that were capable of killing -cells were isolated and characterized from peripheral blood of patients

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SBP reduction was mostly mediated by weight loss (7794%) in SURPASS-1, -2 and -3, while mechanisms independent from weight loss accounted for most of the tirzepatide benefit on SBP in SURPASS-4 and -5 (57 and 73%, respectively) [77]