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Cardiovascular Risk Markers TRIUMPH-4 also assessed a panel of cardiometabolic biomarkers, and the results were broadly favorable across the board: Non-HDL cholesterol significant reductions, indicating improved atherogenic lipid burden Triglycerides meaningful decreases, consistent with the known effects of GLP-1 and GIP receptor activation on lipid metabolism High-sensitivity C-reactive protein (hsCRP) substantial reductions, reflecting decreased systemic inflammation

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What is not documented: long-term safety beyond 24 weeks in humans

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Subcritical water has gained attention due to its non-toxic, non-flammable nature and the absence of solvent residues after extraction (Table 3)

88,89,90 Deng et al