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Gorio A, Di Giulio AM, Tenconi B, et al

Nuclear cataract was observed in patients treated with hyperbaric oxygen therapy, 55 and markedly elevated levels of mature cataract were observed in mice that survived exposure to 100% oxygen twice weekly for 3 hours

However, the corresponding Phe22 residue in OsDHAR is located too far away from the H-site bound GSH (distance between the NH of Phe22 and S of GSH was 6.5 ) for an interaction to occur, even after the conformational change 20

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It is also acylated at position 26 with a chemical side chain containing two acidic groups, one of which is terminally attached