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They found that although SGLT-2I was associated with lower rates of treatment compared to the other 3 drug classes, these latter groups had comparable outcomes compared to each other

2019 Apr;247:285-292

However, their effectiveness can be lower due to reduced absorption

While both arms of the study observed a reduction across all assessed parameters, a greater improvement was seen in the study group, with respect to the control in terms of Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) index, triglyceride levels, BMI, body weight, and waist circumference