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dietary supplementation with glutathione (Reference Kalamkar, Acharya and Kolappurath Madathil72) and vitamins E and C (Reference Ryan, Dudash and Docherty73) have been shown to reduce 8-OHdG in diabetic patients (Reference Kalamkar, Acharya and Kolappurath Madathil72) and aged rats (Reference Ryan, Dudash and Docherty73) , respectively

Myostatin promotes protein degradation by binding to its activating type IIB receptor, which activates the Smad2/Smad3/Smad4 signaling pathway and promotes the expression of Atrogin-1 and MuRF-1[69]