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10 To test whether the induction of p70S6K1 phosphorylation is due to inhibition of IGF-1R signaling pathway not non-specific outcome of OSI-906, the HCT116 cells were treated with other IGF-1R inhibitors, BMS-754807 and GSK1838705A, for 072 h

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Heart rate, respiratory rate, and SpO 2 (oxygen saturation as measured by pulse oximetry) were recorded every 10 min (min) until the end of the EEG recording and 120 min after administration with a Philips IntelliVue MP50 monitor

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