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For individuals with Wilson's disease (a genetic disorder causing copper accumulation) or other copper metabolism disorders, theoretical caution is warranted, though even in these populations topical GHK-Cu is unlikely to pose significant risk given the minimal systemic absorption

2,3 Though both oral and intravenous (IV) formulations of glutathione have been explored in the literature, the evidence regarding their bioavailability, safety, and efficacy remains inconclusive

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During the early healing phase, fibroblasts produce mainly Type III collagen to form the first repair tissue