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The good news is that muscular atrophy on GLP-1s can be mitigated or prevented by lifestyle adjustments

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doi: 10.3390/molecules28145305 329 AtwellLLBeaverLMShannonJWilliamsDEDashwoodRHHoE

Why this result is especially impressive Most people in the SELECT trial were already receiving strong heart-protection medications: ~90% were taking statins many were on blood pressure medicines many were on antiplatelet therapy (like aspirin) So semaglutide helped on top of already excellent medical care

For comparison, metformin, one of the most common diabetes drugs in the world, has oral bioavailability of 40-60%

doi:10.1097/RLU.0000000000002677