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In biochemical and preclinical models, the peptide appears to regulate endothelial activity, cell migration, and cytoskeletal organization through interactions with kinase signaling cascades and nitric oxide related mechanisms

A PDGFR-mediated switch toward CD9 high adipocyte progenitors controls obesity-induced adipose tissue fibrosis

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However, considering lack of longterm treatment data and side effects [81] this class of drug is hardly recommended for the treatment of DPN [82]