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Retatrutide is an investigational triple receptor agonist that simultaneously activates GLP-1, GIP, and glucagon receptors, distinguishing it from approved agents such as semaglutide or tirzepatide

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Immunotherapy approaches are being evaluated for their potential use in Stage 1 (2 islet autoantibodies but normoglycaemia) or Stage 2 (autoantibodies and dysglycaemia) type 1 diabetes to prevent Stage 3 clinical type 1 diabetes, and for the preservation of beta cell function before and shortly after onset of Stage 3 clinical type 1 diabetes [290]