Results showed a significant reduction in Body Mass Index (BMI) over 24 months, with mean differences of 0.36, 1.08, 1.18, and 1.42 at 3, 6, 12, and 24 months, respectively, with 95% CI, and low heterogeneity ( I = 0.0%)
In June 2025, the TGA issued a medicines safety update requiring consideration be given to the risk of delayed gastric emptying and aspiration when providing anaesthesia or deep sedation for patients using these drugs
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GLP-1 receptor agonists have the strongest current evidence base, with multiple randomised controlled trials confirming improvements in insulin resistance, weight, and menstrual regularity
In healthcare, they play a pivotal role in reducing costs for medications and medical supplies by negotiating lower prices and improved contract terms
Bone Density and Joint Health Low IGF-1 correlates directly with reduced bone mineral density.7 GH secretagogues that elevate IGF-1 may support bone remodelling, particularly relevant for older women post-menopause and men experiencing andropause-related testosterone decline
