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Injection-Based Administration Subcutaneous injections: All GLP-1 RAs are administered via subcutaneous injection Prefilled pens: Most common delivery system, allows for self-administration Auto-injectors: Simplify the process for patients with dexterity issues Multi-dose pens: Require dose dialing and needle attachment Dosing frequency: Daily: Liraglutide (Saxenda, Victoza), some formulations of exenatide (Byetta) Weekly: Semaglutide (Wegovy, Ozempic), tirzepatide (Mounjaro, Zepbound), dulaglutide (Trulicity), exenatide extended-release (Bydureon) Titration schedules: Most FDA-approved GLP-1 RAs require gradual dose escalation to minimize gastrointestinal side effects

(PubMed) de Menezes Barbosa EG, Junior FB, Machado AA, Navarro AM

The intestinal mucosa is one of the most rapidly renewing tissues in the body

People with compromised kidney function should be cautious

Take 2 pumps

Ipamorelin is great for fat loss, recovery, and sleep, while CJC-1295 is better for long-term muscle growth and anti-aging