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In practical terms: once-daily SubQ injection of 12 mg is the most common protocol, prioritizing consistency over peak concentration

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Tirzepatide is administered as a once-weekly subcutaneous injection, with dosing typically initiated at 2.5 mg and gradually titrated upward every 4 weeks as tolerated

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HO-1 plays a significant function in vascular tissues by safeguarding endothelial cells from various apoptotic stimuli, thereby regulating endothelial cell cycle control, proliferation, vascular endothelial growth factor (VEGF) secretion, and angiogenesis [94, 95]

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