The classes of antidepressants that are most frequently used in IBS management are the tricyclic antidepressants (TCA), slowing down GI transit, and the selective serotonin reuptake inhibitors (SSRIs), accelerating transit (Ford et al., 2019)
The evidence is plausible and supported by mechanism, but it has not been directly tested in the specific context of GLP-1 induced nausea through a rigorous clinical trial
The most common reason to slow or pause titration is nausea, vomiting, or constipation
Less inflammation means less pain, quicker healing, and stronger, healthier tissues
One of the biggest players is glucagon-like peptide-1, usually shortened to GLP-1
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